Clinical Trials
Professor Saeed is a Principal Investigator on a range of clinical trials as part of his commitment to seek solutions to the challenging ear problems his patients face.
These include the current first in humans REGAIN trail exploring a novel drug injected behind the ear drum for hearing restoration, trials of surgical techniques and outcomes in cochlear implantation and his work on the genetics of otosclerosis. He is also a sub-theme lead for the prestigious UCL/UCL Biomedical Research Centre hearing loss theme.
Grants, Awards & Publications
Research Grants
Professor Saeed has secured over five million pounds of grant income over the last 10 years to support his key areas of clinical and science research. These include:
- Investigating the Genetic Basis of Otosclerosis Co-applicant, Action on Hearing Loss.£160,000, 2014-2016
- National registry of bone conduction implants Lead applicant, MedEl, Innsbruck. £165,000, 2015-2108
- Piezoelectric Nano-Fibre Based Acoustic Sensors for Artificial Cochlea Co-applicant, EPSRC. £870,392, 2015-2020
- Regeneration of inner ear hair cells with gamma-secretase inhibitors to regain hearing inpatients with sensorineural hearing loss Co-applicant, Horizon 2020. Euros 1,204,340, 2015-2020
- NIHR BRC UCLH -Hearing and deafness theme Co-applicant, £2,700,000, 2016-2020
- Investigating the Genetic Basis of Otosclerosis Co-applicant, Action on Hearing loss. £70,000, 2016-2018
- IMPEDANCE_EYE: real-time bioimpedance imaging-guided insertion of cochlear implant electrodes Co-applicant, EPSRC IAA Discovery to Use (D2U). £99,995, 2018-2020
- Novel multimodality imaging techniques for neurosurgical planning in lateral skull basesurgery: a feasibility study. Co-applicant MRC Confidence in Concept (UCL Therapeutic Acceleration Fund).£73,477, 2018-2021
- Improving Brain Tumour Surgery with Intraoperative Hyperspectral Imaging. Coapplicant, National Brain Appeal. £35,000, 2018-2021
- A novel surgical navigation system for skull base surgery Co-applicant, National Brain Appeal. £75,000, 2018-2021
Key recent publications
- The Epidemiology of Otosclerosis in a British Cohort. Crompton M, Cadge BA, Ziff JL, Mowat AJ, Nash R, Lavy JA, Powell HRF, Aldren CP, Saeed SR,
Dawson SJ. Otol Neurotol. 2019 Jan;40(1):22-30. - Evaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners. Carlyon RP, Deeks JM, Guérit F, Lamping W, Billig AJ, Large CH, Saeed SR, Harris P. J Assoc Res Otolaryngol. 2018 Dec;19(6):669-680.
- Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population. Mowat AJ, Crompton M, Ziff JL, Aldren CP, Lavy JA, Saeed SR, Dawson SJ. Hum Genet. 2018 May;137(5):357-363.
- Hearing Preservation With Standard Length Electrodes in Pediatric Cochlear Implantation. Manjaly JG, Nash R, Ellis W, Britz A, Lavy JA, Shaida A, Saeed SR, Khalil SS. Otol Neurotol. 2018 Oct;39(9):1109-1114.
- Outcomes of Transmastoid Surgery for Superior Semicircular Canal Dehiscence Syndrome. Powell HR, Khalil SS, Saeed SR. Otol Neurotol. 2016 Aug;37(7):e228-33
- Mutations and altered expression of SERPINF1 in patients with familial otosclerosis. Ziff JL, Crompton M, Powell HR, Lavy JA, Aldren CP, Steel KP, Saeed SR, Dawson SJ. Hum Mol Genet. 2016 Jun 15;25(12):2393-2403
- A prospective 4-year study of the objective and subjective outcomes of fifteen patients after dynamic facial reanimation surgery.
Andrews P, Randhawa PS, Joseph J, Goh S, Li Q, Poirrier AL, Leong S, Lesser T, Saeed SR. Clin Otolaryngol. 2016 Dec;41(6):825-829. - Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. Taylor RR, Jagger DJ, Saeed SR, Axon P, Donnelly N, Tysome J, Moffatt D4, Irving R, Monksfield P, Coulson C, Freeman SR, Lloyd SK, Forge A. Neurobiol Aging. 2015 Jun;36(6):2068-84.
- The use of cone-beam computed tomography to determine cochlear implant electrode position in human temporal bones. Saeed SR, Selvadurai D, Beale T, Biggs N, Murray B, Gibson P, Risi F, Boyd P. Otol Neurotol. 2014 Sep;35(8):1338-44.
- Cochlear implantation in the mouse via the round window: effects of array insertion. Mistry N, Nolan LS, Saeed SR, Forge A, Taylor RR. Hear Res. 2014 Jun;312:81-90.
Book Chapters
- Cochlear Implants Hall, AC and Saeed SR In Key Topics in Otolaryngology 3rd Edition, 2019
- Vestibular Schwannoma Hall, AC and Saeed SR In Key Topics in Otolaryngology 3rd Edition, 2019
- The Future of Cochlear Implant Design Mitchell-Innes A, Saeed SR, Irving R. In Advances in Otorhinolaryngology, 2018
- Auditory Brainstem Implantation Saeed SR and Powell HRF In Scott-Brown’s Otorhinolaryngology , Head & Neck Surgery 8th Edition, 2018 (section editor Otology)
- Surgical Management of Vestibular Schwannoma Saeed SR and Skilbeck C. In Scott-Brown’s Otorhinolaryngology , Head & Neck Surgery 8th Edition, 2018 (section editor Otology)
- Superior Semicircular Canal Dehiscence Syndrome Saeed SR and Powell HRF In Scott-Brown’s Otorhinolaryngology , Head & Neck Surgery 8th Edition, 2018 (section editor Otology)
- Cerebellopontine angle tumours Skillbeck C and Saeed SR In Logan Turner’s Diseases of the Nose, Throat and Ear, 2015
“Although I knew my hearing, or total lack thereof, was impacting negatively on every part of my life, I remained resistant to CI as I didn’t like to make a fuss, felt I coped brilliantly and was fearful of the surgery
Seeing Prof changed my life. In fact he gave me back not only my life but me. His bluntness about my non functionality, his clarity about the long term impact on the brain of no aural stimulation coupled with the isolation I was choosing acted as the spur I badly needed to move me from denial to acceptance and action
The whole process was extraordinary from beginning to end. And I felt totally safe in Prof’s amazing hands. Like the Wizard of Oz I moved from black and white to full technicolour at switch on. My trajectory was super-fast and that same night I was on the telephone to friends who I’d not been able to call for years.
I no longer stare at peoples lips but look into their eyes, I hear whispers even in the dark, I travel the world, I work again, I listen to birdsong and I hear all the incredible sounds of life around me
CI is a total miracle
I am back from the silent land and daily gratefully full of joy”
Clinician
Leading clinician in disorders of the ear, working in private practice and the NHS
